It is a group of diseases in which inflammatory arthritis characterized by a persistently negative test for rheumatoid factor (RF) is variably associated with a number of other common articular, extra-articular & genetic features.

These disorders develop usually before age 40.

Inflammation of spine, or large peripheral joints, uveitis, and absence of autoantibodies and striking association
with HLA B-27 are characteristics of this group.

This group includes

• Ankylosing spondylitis.

• Reactive arthritis (Reiter’s syndrome).

• Psoriatic arthritis associated with psoriasis

• Enteropathic arthritis associated with
ulcerative colitis and Crohn’s disease

• Bechet’s (Beshets) syndrome

• Juvenile chronic arthritis.

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